Trimethyl Orthoformate as a Highly Selective Mono-C-Methylating Agent for Arylacetonitriles
نویسندگان
چکیده
منابع مشابه
Selective mono-C-methylations of arylacetonitriles and arylacetates with dimethylcarbonate: a mechanistic investigation.
The very high mono-C-methylation selectivity (>99%) of arylacetic acid derivatives (ArCH2X; X = CN, CO2Me) with dimethyl carbonate (DMC) is due to a mechanism that involves consecutive methoxycarbonylation, methylation, and demethoxycarbonylation steps. Important aspects of this mechanism are clarified herein by a kinetic investigation. In the case of arylacetonitriles, at 140 degrees C, the co...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 1998
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo980914s